I knew about this long ago. There was a place in Kingston, NJ, just north of Princeton, called the “Brain-Bio Center”. The physician who worked out of that location - cannot recall his name right off - wrote books and warned of these deficiencies all the way back to the 80’s. He was widely considered a crackpot at the time. I recall a teacher of mine saying, “He’s nuts. A bean is a bean. It can’t grow without having a base level of nutrients.”

Now justified. One reason I keep an ear out for crackpots. You never know!